gene_symbol
ERBB3
hgnc_id
HGNC:3431
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
An anti-HER3 antibody–drug conjugate binds ERBB3 on tumor cells, is internalized, and releases an intracellular cytotoxic payload that kills HER3-expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface HER family receptor; antibody binds extracellular domain on HER3-expressing tumor cells and is internalized to deliver ADC payload; engagement can influence HER3–EGFR/HER3–HER2 dimers.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT07110883
disease_id_num_tar_ref
509
drug_id_num_tar_ref
1415