gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Obinutuzumab binds CD20 on B cells; its Fc engages CD16a (Fc gamma receptor IIIa) on NK cells/macrophages to trigger ADCC/ADCP, killing CD20+ target cells, not the CD16a-expressing effector cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
enhanced affinity via afucosylated Fc
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05918276
disease_id_num_tar_ref
6045
drug_id_num_tar_ref
16388