gene_symbol
IL5RA
hgnc_id
HGNC:6017
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Afucosylated anti–IL-5Rα antibody opsonizes IL-5Rα+ cells and engages FcγRIIIa on NK cells to trigger potent ADCC, leading to perforin/granzyme-mediated apoptosis of eosinophils and basophils.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Primary Fab target on eosinophils and basophils
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05972213
disease_id_num_tar_ref
6050
drug_id_num_tar_ref
16400