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gene_symbol
MS4A1
hgnc_id
HGNC:7315
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Obinutuzumab binds CD20 on B cells and kills them via enhanced ADCC (FcγRIIIa-mediated NK cell cytotoxicity), antibody-dependent phagocytosis by myeloid cells, and induction of direct, caspase-independent cell death; complement involvement is minimal.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Type II anti-CD20 binding to extracellular domain on pre-B and mature B cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05376319
disease_id_num_tar_ref
6058
drug_id_num_tar_ref
16415