gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds HER2 on the tumor cell, is internalized, and releases MMAF intracellularly, inhibiting tubulin polymerization and causing G2/M arrest and apoptosis of the HER2-expressing cell.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ADC antibody (trastuzumab-derived) binds extracellular domain of HER2
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05872295
disease_id_num_tar_ref
6061
drug_id_num_tar_ref
16426