gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC binds HER2 on tumor cells, is internalized, and releases MMAF, which then inhibits beta-tubulin polymerization, causing G2/M arrest and apoptosis. Beta-tubulin-expressing cells are not targeted unless they are HER2+ and receive the payload.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
MMAF payload binds the vinca site on beta-tubulin to inhibit microtubule polymerization; multiple beta-tubulin isoforms may be engaged
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05872295
disease_id_num_tar_ref
6061
drug_id_num_tar_ref
16426