gene_symbol
HLA-A
hgnc_id
HGNC:4931
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Engineered TCR T cells kill AML cells only when HLA-A*02:01 presents the mutant NPM1 peptide; recognition triggers perforin/granzyme-mediated cytotoxicity. HLA-A*02:01 alone is not sufficient for killing.
enzyme_product
Off
epitope
Off
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Peptide–MHC component presenting dNPM1 peptide to engineered TCR
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06424340
disease_id_num_tar_ref
510
drug_id_num_tar_ref
1416