gene_symbol
MS4A1
hgnc_id
HGNC:7315
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Obinutuzumab binds CD20 on B cells and induces killing via enhanced Fc-gamma RIIIa–mediated ADCC (NK cells/monocytes), antibody-dependent phagocytosis, and direct type II, caspase-independent B-cell death, with minimal reliance on complement.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Type II anti-CD20; glycoengineered Fc for enhanced FcγRIIIa affinity
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05943496
disease_id_num_tar_ref
6086
drug_id_num_tar_ref
16496