gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The anti-HER2 ADC binds HER2 on tumor cells, is internalized, and releases MMAE, which disrupts microtubules causing G2/M arrest and apoptosis; it may also trigger ADCC and bystander killing.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
cell-surface receptor tyrosine kinase
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05586061
disease_id_num_tar_ref
6104
drug_id_num_tar_ref
16551