gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Disitamab vedotin targets HER2 on the cell surface; after HER2-mediated internalization it releases MMAE, which binds the vinca site on beta-tubulin to inhibit microtubule polymerization, causing G2/M arrest and apoptosis. Beta-tubulin expression alone does not determine killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
target of MMAE; microtubule polymerization inhibitor
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05586061
disease_id_num_tar_ref
6104
drug_id_num_tar_ref
16551