gene_symbol
TNFRSF4
hgnc_id
HGNC:11918
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The anti-OX40 IgG1 antibody binds OX40 on activated T cells and engages Fcγ receptor–bearing effector cells to mediate ADCC (and potentially CDC), depleting OX40-expressing T cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Antagonist; blocks OX40–OX40L costimulation and depletes OX40+ T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05899816
disease_id_num_tar_ref
6108
drug_id_num_tar_ref
16561