gene_symbol
ENG
hgnc_id
HGNC:3349
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
IgG1 antibody binds CD105 on endothelial cells and engages Fcγ receptors on effector cells (e.g., NK cells) to trigger ADCC, killing CD105+ cells; angiogenesis blockade is indirect.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
TGF-beta coreceptor on proliferating endothelial cells; also binds soluble endoglin
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05534646
disease_id_num_tar_ref
6116
drug_id_num_tar_ref
16588