gene_symbol
TNF
hgnc_id
HGNC:11892
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Infliximab binds membrane TNF-alpha on cells and, via its IgG1 Fc, recruits Fc gamma receptor effector cells for ADCC and activates complement (CDC); reverse signaling through mTNF can also trigger apoptosis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds both soluble and transmembrane TNF (sTNF and tmTNF), blocking TNFR1/2 engagement; Fc can mediate ADCC/CDC against TNF-expressing cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05424926
disease_id_num_tar_ref
6117
drug_id_num_tar_ref
16589