gene_symbol
MSLN
hgnc_id
HGNC:7371
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Mesothelin-specific CAR T cells bind mesothelin on target cells and kill them via T-cell cytotoxic pathways (perforin/granzyme release and death-receptor signaling); IL-21–anti-PD-1 scFv enhances activation/persistence.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
CAR scFv-mediated recognition of tumor-associated antigen
trial_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05779917
disease_id_num_tar_ref
6126
drug_id_num_tar_ref
16609