gene_symbol
PDCD1
hgnc_id
HGNC:8760
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The drug secretes an anti-PD-1 scFv that blocks PD-1 signaling to boost CAR-T activation; it does not target or kill PD-1-expressing cells. Cytotoxicity is directed against mesothelin-positive tumor cells via CAR-mediated T-cell killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Locally secreted anti-PD-1 scFv provides checkpoint blockade
trial_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05779917
disease_id_num_tar_ref
6126
drug_id_num_tar_ref
16609