gene_symbol
IL21R
hgnc_id
HGNC:6006
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The CAR T cells kill mesothelin-positive tumor cells via T-cell cytotoxicity (perforin/granzyme, Fas/FasL) after CAR engagement. The secreted IL-21–anti-PD-1 scFv binds IL-21R on immune cells to enhance T-cell function but does not target IL-21R-expressing cells for killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
IL-21 domain of the secreted fusion engages IL21R (with IL2RG co-receptor)
trial_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05779917
disease_id_num_tar_ref
6126
drug_id_num_tar_ref
16609