gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC binds BCMA (not tubulin), is internalized, and releases MMAF, which inhibits beta‑tubulin polymerization to cause G2/M arrest and apoptosis; Fc-mediated ADCC/ADCP may also contribute.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
vinca-domain binding by MMAF payload; inhibits tubulin polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05833737
disease_id_num_tar_ref
6136
drug_id_num_tar_ref
16639