gene_symbol
CD274
hgnc_id
HGNC:17635
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds PD-L1 on target cells, is internalized, and releases a camptothecin-based topoisomerase I inhibitor that causes DNA damage and apoptosis (with potential bystander killing).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
cell-surface immune checkpoint ligand targeted by ADC antibody
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06115642
disease_id_num_tar_ref
6144
drug_id_num_tar_ref
16656