gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Cetuximab binds EGFR on target cells and its IgG1 Fc engages Fcγ receptors on NK cells to trigger antibody-dependent cellular cytotoxicity (ADCC), killing EGFR+ cells (with possible complement-mediated cytotoxicity). Signaling blockade is primarily cytostatic.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain (domain III) to block ligand binding and receptor dimerization; IgG1 Fc enables ADCC.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05930938
disease_id_num_tar_ref
6153
drug_id_num_tar_ref
16675