gene_symbol
ROR1
hgnc_id
HGNC:10256
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
T-cell redirected cytotoxicity: the tetra-specific engager binds ROR1 on tumor cells and CD3 on T cells, provides 4-1BB costimulation and blocks PD-L1, activating CTLs to kill ROR1+ cells via perforin/granzyme-mediated lysis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
tumor-associated antigen on malignant B cells; mediates tumor cell engagement
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05944978
disease_id_num_tar_ref
6157
drug_id_num_tar_ref
16684