gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The drug binds CD3 on T cells to recruit and activate them; these T cells are then redirected to kill ROR1+ tumor cells (enhanced by PD-L1 blockade and 4-1BB costimulation) via perforin/granzyme-mediated cytolysis. CD3+ T cells themselves are not the targets of killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
T-cell redirector via CD3 complex; likely CD3E subunit
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05944978
disease_id_num_tar_ref
6157
drug_id_num_tar_ref
16684