gene_symbol
TACSTD2
hgnc_id
HGNC:11530
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds TROP-2, is internalized, and releases SN-38 (topoisomerase I inhibitor) inside the cell, causing DNA damage and apoptosis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Recognized by anti-TROP-2 monoclonal antibody (hRS7) on tumor cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05633667
disease_id_num_tar_ref
6165
drug_id_num_tar_ref
16704