gene_symbol
PDGFRB
hgnc_id
HGNC:8804
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Imatinib directly inhibits PDGFRβ’s tyrosine kinase activity (ATP-competitive), shutting down PDGFR signaling (e.g., RAS/MAPK, PI3K/AKT) and inducing growth arrest and apoptosis in PDGFRβ-driven cells.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06682169
disease_id_num_tar_ref
515
drug_id_num_tar_ref
1425