gene_symbol
CD79B
hgnc_id
HGNC:1699
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds CD79b on B cells, is internalized, linker is cleaved, and MMAE is released to inhibit tubulin polymerization, causing G2/M arrest and apoptosis of CD79b-positive cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface B-cell receptor component; internalization enables payload release
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05940064
disease_id_num_tar_ref
6170
drug_id_num_tar_ref
16724