gene_symbol
KRAS
hgnc_id
HGNC:6407
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Engineered TCR-T cells recognize the KRAS G12V peptide presented by HLA-A*11:01 and directly kill target cells via TCR-triggered cytotoxic effector functions (perforin/granzyme and Fas–FasL), MHC class I–restricted.
enzyme_product
On
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
MHC class I–restricted pMHC target
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05933668
disease_id_num_tar_ref
6177
drug_id_num_tar_ref
16745