gene_symbol
HLA-A
hgnc_id
HGNC:4931
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Engineered TCR-T cells kill only cells presenting the KRAS G12V peptide bound to HLA-A*11:01 via TCR engagement, triggering perforin/granzyme-mediated cytotoxicity (MHC I–restricted). HLA-A*11:01 alone is not sufficient.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Restriction element required for TCR binding to KRAS G12V peptide
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05933668
disease_id_num_tar_ref
6177
drug_id_num_tar_ref
16745