gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds HER2, is internalized, and delivers the DM1 microtubule inhibitor inside HER2+ cells, disrupting microtubules to cause mitotic arrest and apoptosis; trastuzumab’s Fc can also mediate ADCC.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Trastuzumab antibody moiety binds the extracellular domain of HER2
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06126640
disease_id_num_tar_ref
6182
drug_id_num_tar_ref
16763