gene_symbol
TACSTD2
hgnc_id
HGNC:11530
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds TROP2 on tumor cells, is internalized, and releases a topoisomerase I inhibitor that induces DNA damage, replication arrest, and apoptosis; membrane-permeable payload can also cause a bystander effect.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface transmembrane glycoprotein; ADC binding and internalization target
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05642780
disease_id_num_tar_ref
6188
drug_id_num_tar_ref
16775