gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The antibody binds tumor antigens with its Fab and engages CD16A on NK cells via its Fc to trigger ADCC (and also ADCP/CDC), killing the antibody-opsonized tumor cells; CD16A+ cells are effectors, not targets of killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc-mediated binding; primary ADCC on NK cells.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06154291
disease_id_num_tar_ref
6196
drug_id_num_tar_ref
16795