gene_symbol
FCGR2A
hgnc_id
HGNC:3616
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
XON7 opsonizes tumor antigens and engages Fcγ receptors (including CD32A) on immune effectors to drive ADCC/ADCP and CDC against the antibody-coated tumor cells; CD32A+ cells act as effectors, not targets of killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc-mediated binding; ADCP on macrophages and neutrophils.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06154291
disease_id_num_tar_ref
6196
drug_id_num_tar_ref
16795