gene_symbol
FCGR1A
hgnc_id
HGNC:3613
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The antibody binds tumor antigens via Fab and engages CD64 (Fc gamma receptor I) on macrophages/monocytes through its Fc to trigger ADCC/ADCP and complement (CDC) against antibody-coated tumor cells; CD64+ cells act as effectors, not targets.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
High-affinity FcγRI; ADCP on macrophages/monocytes.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06154291
disease_id_num_tar_ref
6196
drug_id_num_tar_ref
16795