gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Obinutuzumab binds CD20 on B cells and engages CD16a (FcγRIIIa) on NK cells/macrophages via its Fc to trigger ADCC/ADCP, killing CD20+ cells; CD16a-expressing effector cells are not killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc-mediated engagement; enhanced affinity due to glycoengineering/afucosylation
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06084936
disease_id_num_tar_ref
6198
drug_id_num_tar_ref
16800