gene_symbol
CD1A
hgnc_id
HGNC:1634
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CD1a CAR-T cells bind CD1a and, upon CAR activation (CD3ΞΆ with costimulation), kill targets via cytolytic degranulation (perforin/granzymes) and apoptotic/lytic pathways.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface antigen on cortical T-ALL/LBL; HLA-independent CAR binding
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05745181
disease_id_num_tar_ref
6206
drug_id_num_tar_ref
16827