gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR T cells recognizing the EGFR806 epitope on EGFR/EGFRvIII bind target cells and, upon CAR engagement, execute cytolytic killing via perforin/granzyme release and death-receptor pathways.
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Tumor-restricted mAb806 epitope; low affinity for WT EGFR; recognizes EGFRvIII and activated/overexpressed EGFR
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05768880
disease_id_num_tar_ref
6212
drug_id_num_tar_ref
16844