gene_symbol
IL13RA2
hgnc_id
HGNC:5975
binding_type
receptor ligand recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR T cells engineered with an IL13-zetakine bind IL13Ralpha2 on tumor cells, triggering T-cell activation and perforin/granzyme-mediated cytolysis and apoptosis (with possible Fas–FasL/cytokine contributions).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
IL13-zetakine CAR uses IL-13 mutein ligand to bind IL13Rα2
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05768880
disease_id_num_tar_ref
6212
drug_id_num_tar_ref
16844