gene_symbol
CD274
hgnc_id
HGNC:17635
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Blocks PD-L1/PD-1 to relieve inhibition and conditionally agonizes 4-1BB on T cells near PD-L1+ tumors, enhancing TCR-dependent T‑cell killing (perforin/granzyme) of PD-L1–expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Blocking/antagonist binding to prevent PD-L1–PD-1 interaction
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06157827
disease_id_num_tar_ref
6214
drug_id_num_tar_ref
16848