gene_symbol
PVRL4
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds Nectin-4 on target cells, is internalized, and releases MMAE after linker cleavage; MMAE inhibits tubulin polymerization, causing G2/M arrest and apoptosis of Nectin-4–expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface adhesion molecule; ADC binding/internalization target
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05923190
disease_id_num_tar_ref
6215
drug_id_num_tar_ref
16853