gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC binds Nectin-4 on tumor cells, is internalized, and releases MMAE, which binds beta-tubulin to inhibit microtubule polymerization causing G2/M arrest and apoptosis; beta-tubulin is not the targeted antigen determining cell killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Vinca site; microtubule polymerization inhibitor (MMAE payload)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05923190
disease_id_num_tar_ref
6215
drug_id_num_tar_ref
16853