gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC binds HER2 (not beta‑tubulin), is internalized, and releases MMAE, which inhibits beta‑tubulin–dependent microtubule polymerization to cause G2/M arrest and apoptosis; beta‑tubulin is the intracellular payload target, not the drug’s binding target.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
MMAE payload binds the vinca domain on beta-tubulin to inhibit polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06001086
disease_id_num_tar_ref
6229
drug_id_num_tar_ref
16886