gene_symbol
IL3RA
hgnc_id
HGNC:6012
binding_type
receptor ligand recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
IL-3 moiety binds CD123, the fusion protein is internalized, and the diphtheria toxin domain ADP-ribosylates EF-2 to block protein synthesis, causing cell death.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Primary cell-surface binding target of IL-3 moiety
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05720988
disease_id_num_tar_ref
523
drug_id_num_tar_ref
1447