gene_symbol
EEF2
hgnc_id
HGNC:3214
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The drug binds CD123 on target cells, is endocytosed, and its diphtheria toxin domain ADP-ribosylates EF-2 to halt protein synthesis, causing cell death; EF-2 is an intracellular substrate, not the targeted antigen determining specificity.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Intracellular catalytic substrate; ADP-ribosylated by diphtheria toxin domain
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05720988
disease_id_num_tar_ref
523
drug_id_num_tar_ref
1447