gene_symbol
MICB
hgnc_id
HGNC:7091
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR NK cells bind the alpha-3 domain of MICB on target cells, activating NK degranulation and perforin/granzyme-mediated lysis; hnCD16 can also drive ADCC when targets are antibody-opsonized.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Alpha-3 domain-specific CAR binding; NKG2D-ligand; shedding-resistant epitope
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06342986
disease_id_num_tar_ref
525
drug_id_num_tar_ref
1450