gene_symbol
IGHG1
hgnc_id
HGNC:5525
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
FT536 NK cells use hnCD16 to bind the Fc region of therapeutic antibodies coating tumor cells, triggering ADCC against the antibody‑opsonized cells. The IgG Fc region itself is not a cellular antigen targeted for killing; direct killing is via the CAR to MICA/MICB on tumor cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc engagement via high-affinity, non-cleavable CD16 (FcγRIIIa) to mediate ADCC when tumor-bound antibodies are present
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06342986
disease_id_num_tar_ref
525
drug_id_num_tar_ref
1450