gene_symbol
TP53
hgnc_id
HGNC:11998
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Engineered TCR T cells recognize the TP53 R248Q peptide–HLA-A*11:01 complex and directly lyse target cells via TCR-activated perforin/granzyme cytotoxicity (and Fas–FasL pathways).
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Peptide–MHC class I complex; HLA-A*11:01–restricted
trial_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06619886
disease_id_num_tar_ref
530
drug_id_num_tar_ref
1467