gene_symbol
HLA-A
hgnc_id
HGNC:4931
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Engineered TCR T cells recognize the TP53 R248Q peptide presented by HLA-A*11:01 on target cells and directly kill them via TCR-triggered cytolytic synapse with perforin/granzyme release (and death receptor/cytokine-mediated apoptosis).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Allele-specific restriction (A*11:01); TCR recognizes peptide–HLA complex
trial_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06619886
disease_id_num_tar_ref
530
drug_id_num_tar_ref
1467