gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Sacituzumab govitecan binds Trop-2 on cells, is internalized, and releases SN-38, which inhibits topoisomerase I to cause DNA damage and apoptosis; topoisomerase I is the intracellular payload target, not the antigen determining cell targeting.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Enzymatic target of SN-38 payload; enzyme poisoning inhibits DNA replication
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06161532
disease_id_num_tar_ref
533
drug_id_num_tar_ref
1472