gene_symbol
BCL2
hgnc_id
HGNC:990
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Venetoclax binds and inhibits anti-apoptotic BCL-2, freeing pro-apoptotic effectors (e.g., BAX/BAK) to induce mitochondrial outer membrane permeabilization, caspase activation, and intrinsic apoptosis in BCL-2–dependent cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds BH3-binding hydrophobic groove of anti-apoptotic BCL-2
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06158100
disease_id_num_tar_ref
542
drug_id_num_tar_ref
1496