gene_symbol
FCGR1A
hgnc_id
HGNC:3613
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Naxitamab binds GD2 on tumor cells via its Fab; its Fc engages CD64 (FcγRI) on myeloid effector cells to drive ADCC/ADCP (and complement can lyse GD2+ cells). CD64+ cells serve as effectors and are not killed by the drug.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
High-affinity Fc receptor on myeloid cells supporting ADCP
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06574698
disease_id_num_tar_ref
546
drug_id_num_tar_ref
1505