gene_symbol
CD47
hgnc_id
HGNC:1682
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Blocks CD47–SIRPα “don’t‑eat‑me” signaling, enabling macrophage antibody‑dependent cellular phagocytosis (ADCP) of CD47+ cells; can also secondarily augment anti‑tumor T‑cell responses.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Blocks CD47–SIRPA interaction to remove the 'don’t-eat-me' signal and enable macrophage phagocytosis
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05829434
disease_id_num_tar_ref
559
drug_id_num_tar_ref
1544