gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Binds HER2 on tumor cells and engages Fcγ receptor–bearing immune cells to mediate ADCC, causing lysis/apoptosis of HER2+ cells (with additional growth inhibition via signaling blockade).
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain IV
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06641544
disease_id_num_tar_ref
566
drug_id_num_tar_ref
1568